Gout linked to 376 genetic variants in a study of 2.6 million people


As well as being caused by eating an indulgent diet, gout has been linked to hundreds of genetic variants in the largest study of its kind


16 December 2022

X-ray of feet affected by gout

X-ray of feet affected by gout


Almost 400 genetic variants have been linked to gout in the largest study of its kind.

Gout is a type of arthritis that leads to painful flare-ups around joints. The condition is caused by a build-up of uric acid, or urate, from the breakdown of molecules called purines. This causes urate crystals to form in joints, leading to a painful inflammatory response.

Purines are made in the body and found in certain foods and drinks, such as bacon and beer. Drinking alcohol in moderation …


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